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as illustrated in Figure 8.1. While additional capacity can obviously be added, the above process is very time-consuming. For example, the process of laying down new ber-optic cables is a lengthy and expensive process, with substantial use of manual labor. The situation is very different in MANETs due to the scarcity of over-theair bandwidth and due to the fact spare capacity is not readily available. In fact, in MANETs, it is very often the case that the amount of network capacity

Another example of racial differences in drug responsiveness is variations in the CYP 2D6 gene, which codes for the enzyme responsible for the metabolism of beta-blockers and tricyclic antidepressants The gene is functionally absent in 8% of whites and 4% of Asians, but it is missing in 25% of African Americans because of an allele generally not found in those other groups Those lacking the enzyme would be at a risk of excess a-adrenergic blockade and severe toxicity from inability to metabolize the drug that those without the variation avoid In some cases, lowering the dosage will alleviate the toxicity and preserve some therapeutic effect In other cases, the drug will be contraindicated altogether, and some other drug will be needed to treat the condition Whether the variations interfere with receptors, enzymes, or particular cellular pathways, they affect the ability to metabolize drugs (Wood, 2001).

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, it is used in all process modeling at the telecommuncations company Ericsson), and it doesn t overlap with any existing symbol in UML In formal UML, the symbol is a stereotyped activity (an action state) from an activity diagram; it is also the UML activity diagram that is used to illustrate business processes A process that is, an activity stereotyped to process takes input resources from its left-hand side and indicates its output resources on its right-hand side The goal of the process is either illustrated as a goal object above the process symbol or, more informally, specified in the tagged value Goal of the process (the tagged value is not visible in the diagram but is available in a tool) Resource objects used as part of the process are shown below the process symbol.

For emphasis, we repeat: Unless the top tiers of the leadership hierarchy recognize the importance of knowledge exchange in the culture, there is little hope that grass-roots efforts will transform the entire organization. Some individuals in the company may pursue learning from each other, but knowledge as a driver of success and change throughout the organization will not be significant.

Identifying them in advance would greatly aid physicians in deciding the best course of treatment Racial and ethnic differences in drug response are important clinically, but they also show the importance of the underlying genetic determinants of drug response Once scientists identify the genetic determinants of differential response to drugs for heart disease, such as enalapril and carvedilol, the genetic variations can be tested for directly In the future, DNA microarrays will be able to test for many drug response genotypes simultaneously, thus avoiding the need to rely on appearance and self-reports of race and.

A special variant of an activity diagram, the aforementioned assembly line diagram, can be introduced to show how a process interacts with a specific resource (eg, an information system) The assembly line diagram illustrates resource objects that are affected by the process in one or more assembly lines below the process The objects in the assembly line are typically information objects from which information is read or written during the execution of the process Assembly line diagrams are shown and discussed in more detail in 4, Business Views..

With any apparently good managerial improvement method, there are also dark sides One way to explore the dark side of applying scorecards is to imagine that you are an IT security manager, the person who controls passwords and determines who has access to which data Pretend that you control the switches for all of your organization s employees access to potentially all of the scorecards the enterprise as well as the local scorecards Let s assume that all employee teams have unprotected visibility to all of the scorecards above them that is, access to their more senior managers scorecards with strategy-mapped paths and linkages, all the way to the chief executive of cer s scorecard that sits on top of the enterprise scorecard.

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