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the 18 basic traits that ranged from .26 for Intimacy Problems to .48 for Conduct Problems. These studies, in contrast to studies of phenotypic structure, point to the signi cance of the lower-order traits. Although these traits have tended to be neglected in personality research, they appear to be important for understanding personality. This suggests that a bottom-up approach to personality structure would provide additional information to complement that provided by the traditional top-down approach of the three- and ve-factor models that identify the higher-order domains rst and then seek to de ne an appropriate complement of facet traits. Before considering these issues in greater depth, it is important to recognize a limitation of the methods used. The regression method does not model genetic effects directly, and the results need to be replicated using multivariate genetic analyses. This introduces another feature of behavioral genetic analyses that is pertinent to

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Yet using rows 5 and 6 of Table 207, one gets (006/963)/(006/955) = 992 However, if the probabilities in Table 207 are carried out to ve signi cant digits, we actually get (0063/96282)/ (00593/95483) = 1054) Ordered Categorical Variables When the values of a categorical variable are ordered, it is usually wise to take advantage of that information in model speci cation For example, the trichotomous categorization of violence used for the analyses in Tables 206 and 207 represents different degrees of violence severity, as mentioned previously In this section I treat it as an ordinal variable The ordered logit model is a variant of logistic regression speci cally designed for ordinal-level dependent variables Although there is more than one way to form logits for ordinal variables (see, eg.

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, and Stull, ND (1997) Expression of tyrosine hydroxylase in newly differentiated neurons from a human cell line (hNT) Neuroreport 8: 1471 1474 Jaeger, CB, Greene, LA, Tresco, PA, Winn, SR, Aebischer, P (1990) Polymer encapsulated dopaminergic cell lines as alternative neural grafts Prog Brain Res 82: 41 46 Johnston, RE, and Becker, JB (1999) Behavioral changes associated with grafts of embryonic ventral mesencephalon tissue into the striatum and/or substantia nigra in a rat model of Parkinson s Disease Behav Brain Res 104: 179 187 Kim, JH, Auerbach, JM, Rodriguez-Gomez, JA, Velasco, I, Gavin, D, Lumelsky, N, Lee, SH, Nguyen, J, Sanchez-Pernaute, R, Bankiewicz, K, McKay, R (2002) Dopamine neurons derived from embryonic stem cells function in an animal model of Parkinson s disease.

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, Agresti, 1984, 1989, for other formulations), I shall focus on cumulative logits These are especially appropriate if the dimension represented by the ordinal measure could theoretically be regarded as continuous (Agresti, 1989) Cumulative logits are de ned as follows Suppose that the response variable consists of J ordered categories coded 1, 2, , J The j th cumulative odds is the ratio of the probability of being in category j or lower on Y to the probability of being in category j + 1 or higher That is, if O j represents the j th cumulative odds and j is the probability of being in category j on Y , then O j = + + j+1.

Nature 418: 50 56 Kim, KT, Park, DH, Joh, TH (1993) Parallel up-regulation of catecholamine biosynthetic enzymes by dexamethasone in PC12 cells J Neurochem, 60: 946 951 Klaus, DM (2001) Clinostats and bioreactors Gravit Space Biol Bull 14: 55 64 Lelkes, PI (1991) Our PC12 cells are not your PC12 cells which are not his/her PC12 cells 6th International Symposium for Chromaf n Cell Biology, Marburg, Germany, 1991 Lelkes, PI, Galvan, DL, Hayman, GT, Goodwin, TJ, Chatman, DY, Cherian, S, Garcia, RM, Unsworth, BR (1998) Simulated microgravity conditions enhance differentiation of cultured PC12 cells towards the neuroendocrine phenotype In Vitro Cell Dev Biol 34: 316 325 Lelkes, PI, Ramos, E, Chick, DM, Liu, J, Unsworth, BR.

In Exhibit 21, note that net food cost has been deducted from revenue to arrive at gross margin (gross profit) before deducting other departmental expenses To arrive at net food cost and net beverage cost, some calculations are necessary to match up food and beverage sales with cost of the food and beverage inventory sold, or to find the net cost of sales incurred to generate those sales In the first chapter, we discussed methods to determine the monthly cost of sales using the periodic inventory control method The periodic method relies on a physical count and costing of the inventory to determine the cost of sales Using the periodic method normally will not provide a record of inventory available for sale on any particular day.

(1994) Microgravity decreases tyrosine hydroxylase expression in rat adrenals FASEB J 8: 1177 1182 Lelkes, PI, Ramos, E, Nikolaychik, VV, Wankowski, DM, Unsworth, BR, Goodwin, TJ (1997) GTSF-2: a new, versatile cell culture medium for diverse normal and transformed mammalian cells In Vitro Cell Dev Biol Anim 33: 344 351..

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