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Table 26 4 Factors that may cause aberrations in laboratory tests that may be mistaken for primary hypothyroidism1

Low Serum T4 or T3 Laboratory error Acute psychiatric problems Cirrhosis Nephrotic syndrome Familial thyroid-binding globulin deficiency Severe illness Drugs Androgens Asparaginase Carbamazepine Chloral hydrate Corticosteroids Diclofenac (T3) Fenclofenac Flouracil Halofenate Mitotane Naproxen (T3) Nicotinic acid Oxcarbazepine Phenobarbital Penytoion (total T4 may be as low as 2 mcg/dL) Salicylates (large doses T3 and T4) Sertraline T3 therapy True primary hypothyroidism may coexist T4, levothyroxine; T3, triiodothyronine; TSH, thyroid-stimulating hormone

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Table 26 5 Factors that can cause aberrations in laboratory tests that may be mistaken for spontaneous clinical primary hyperthyroidism1

In the new interface definition, use the colon operator followed by the name of the original interface This is very similar to derivation in classes The extended interface subsumes the original interface, so any class that implements the extended interface must also implement the original interface as well A class that implements an interface may mark any of the interface methods as virtual These methods may then be overridden by derived classes When a class implements two or more interfaces with methods that have the same name, you resolve the conflict by prefixing the method name with the name of the interface and the dot operator (for example, IStorableWrite( )) If you do this, you cannot specify an access modifier, as the method is implicitly public.

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High Serum T4 or T3 Laboratory error Collecting serum in vial with gel barrier T3 Acute psychiatric problems (30%) Acute medical illness (eg, acute intermittent porphyria AIDS (increased thyroidbinding globulin) Autoimmunity Hepatitis: acute or chronic active Primary biliary cirrhosis Pregnancy (especially with morning sickness) Hypermesis gravidarum Familial thyroid-binding abnormalties Famial generalized resistance to thyroid (Refetoff syndrome) Drugs Amiodarone Amphetamines Clofibrate Estrogens (oral) Heparin (dialysis method) Heroin Thyroid hormone therapy Methadone Perphenazine Tamoxifen True clinical hyperthyroidism may coexist T4, levothyroxine; T3, triiodothyronine; TSH, thyroid-stimulating hormone; hCG, human chorionic gonadotropin; NSAIDs, nonsteroidal anti-inflammatory drugs

High Serum TSH Laboratory error Autoimmune disease (assay interference) Heterophile antibodies Anti-mouse antibodies Strenuous exercise (acute) Sleep deprivation (acute) Recovery from nonthyroidal illness (transient) Acute psychiatric admissions (14% transient) Elderly especially women (10%, mild elevations) Low Serum TSH Laboratory error Autonomous thyroid or thyroid nodule Acute corticosteroid administration Elderly euthyroid Nonthyroidal illness (severe) Pregnancy (especially with morning sickness) hCG-secreting trophoblastic tumors Drugs Thyroid hormone Amphetamines Dopamine Dopamine agonists

Calcium channel blockers (nifedipine, verapamil)

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You saw in this chapter how interfaces encourage polymorphism, allowing you to dictate the methods your classes implement, while still providing flexibility in your designs They re admittedly somewhat tricky to understand at first, but as you get more practice with them, you ll get more comfortable with them In this chapter, you used arrays to demonstrate the polymorphic features of interfaces, and that s a pretty.

dema Hyponatremia is the result of impaired renal tubular sodium reabsorption due to reductions in Na+ K+-ATPase Hypothyroidism may be due to primary disease of the thyroid gland itself or lack of pituitary TSH Florid hypothyroidism, ie, myxedema and cretinism, is readily recognized on clinical grounds alone, but mild hypothyroidism often escapes detection without screening (ie, serum TSH) Maternal hypothyroidism during pregnancy results in offspring with IQ scores that are an average 7 points lower than those of euthyroid mothers Goiter may be noted when hypothyroidism is due to Hashimoto s thyroiditis, iodide deficiency, genetic thyroid enzyme

defects, drug goitrogens (lithium, iodide, propylthiouracil or methimazole, phenylbutazone, sulfonamides, amiodarone, interferon- , interferon- , interleukin-2), food goitrogens in iodide-deficient areas (eg, turnips, cassavas) or, rarely, peripheral resistance to thyroid hormone or infiltrating diseases (eg, cancer, sarcoidosis) A hypothyroid phase occurs in subacute (de Quervain s) viral thyroiditis following initial hyperthyroidism Goiter is usually absent when hypothyroidism is due to deficient pituitary TSH secretion, or destruction of the gland by surgery, external radiation, or 131I Patients who have

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