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Genotype AA Initial genotypic frequencies Fitness (W ) Ratio after selection Genotypic frequencies after selection p 1.5 p2(1.5 p2(1.5 W

x(t) a(t)

Solution:

larva but selected against in an adult. There can also be a balance of selection in different parts of the habitat in a heterogeneous environment. For instance, an allele can be favored in a wet part of the habitat but selected against in a dry part.

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First we apply KVL around the electrical circuit to write the differential equation describing the electrical system: di dx + (Rcoil + Rout )i + Bl =0 dt dt Also note that vout = Rout i Next, we write the differential equation describing the mechanical system The magnet experiences an inertial force due to the acceleration of the supporting body, a(t), and to its own relative acceleration, d 2 x/dt 2 ; thus, we can sketch a free-body diagram and apply Newton s second law to the permanent magnet, as shown in the sketch L M a+ d 2x dt 2 +d dx + kx = Bli dt

Fig 83: Relative sizes of MEMS devices with the dimension in meters [4]

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Finally, using the Laplace transform, we determine the transfer function from A(s) to Vout (s) Let R = Rcoil + Rout Then (Ls + R)I (s) + BlsX(s) = 0 BlI (s) (Ms 2 + Ds + K)X(s) = MA(s) Since we need the transfer function from A to Vout , we use the expression Vout (s) = Rout I (s) and, after some algebra, nd that I (s) = or Vout (s) MBsRout = A(s) (Ls + R)(Ms 2 + Ds + K) + B 2 l 2 s MBlsA(s) (Ls + R)(Ms 2 + Ds + K) + B 2 l 2 s

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In summary, allelic polymorphisms in a population were classically accounted for by heterozygote advantage, frequency-dependent selection, or, infrequently, some other mechanism. Until Lewontin and Hubby did their work, heterozygote advantage was considered the most common method of maintaining a polymorphism at a given locus. The maintenance of an allele by heterozygote advantage costs the population a certain number of its offspring due to the mortality (or sterility) of the homozygotes. Most populations can afford the loss if polymorphisms are maintained at only a few loci. After Lewontin and Hubby reported that polymorphisms seemed to exist at a large proportion of loci, new explanations were needed to account for them. Three explanations were considered: 1. Electrophoresis (the technique used in Lewontin and Hubby s research) does not randomly sample the genome, and thus the large amount of variability they found does not really exist. 2. New population genetic models can be derived that explain how natural selection maintains this large amount of variability. 3. Electrophoretic alleles are not under selective pressure.That is, allozymic forms of an enzyme all perform the function of the enzyme equally well. This idea is called the neutral gene hypothesis.

A loudspeaker, shown in Figure 1653, uses a permanent magnet and a moving coil to produce the vibrational motion that generates the pressure waves we perceive as sound Vibration of the loudspeaker is caused by changes in the input current to a coil; the coil is, in turn, coupled to a magnetic structure that can produce time-varying forces on the speaker diaphragm A simpli ed model for the mechanics of the speaker is also shown in Figure 1653 The force exerted on the coil is also exerted on the mass of the speaker diaphragm, as shown in Figure 1654, which depicts a free-body diagram of the forces acting on the loudspeaker diaphragm

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