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Ion channels of excitable cells consist of a narrow pore, of a gate that opens and closes the access to the pore, and of a sensor that reacts to the stimuli from outside and issues instructions to the gate The outer stimuli are either a potential change or binding of a specific compound to the sensor The nerve axon sodium channel was studied in detail (in fact, as shown by the power spectrum analysis, there are two sorts of this channel: one with fast opening and slow inactivation and the other with opposite properties) It is a glycoprotein consisting of three subunits (Fig 622), the largest (mol wt 35 x 105) with a pore inside and two smaller ones (molwt 35 x 104 and 33 x 104) The attenuation in the orifice of the pore is a kind of a filter.

IsArray()

Returns Yes if value is an array; otherwise, No. Also tests whether array is of dimension dimension, if supplied.

10 20 30

IsArray( value, dimension)

Duplicate()

Cymbals, toms, hi-hats, and other percussion can often be panned somewhat to the left and right, maintaining an overall balance Guitars can be panned, sometimes with two distorted guitars panned one to each side As the frequency of a sound increases, the ear s sensitivity to spatial placement increases as well You can place the subwoofer of a stereo system off-center, and it will still sound good, but if you misplaced a tweeter, it would sound lopsided Due to the ear s increased sensitivity, take extra care to balance the high frequencies between the left and right channels..

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Returns a deep copy of variableName. No referential connection exists between variableName and its duplicate returned from this function, so setting a value in the deep copy has no effect on the corresponding value in variableName.

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Duplicate( variableName)

IsStruct()

E E 60 70 80-

IsStruct( value)

StructAppend()

To create convincing front/back spatial relationships, you ll need to use a combination of techniques outside of the realm of panning. To make a track sound farther back: Lower the volume. Increase the amount of reverb and delay. Use a high shelf filter to roll off the higher frequencies. The use of filters and reverb is discussed later in this chapter.

Returns Yes if successfully appends the keys from structure2 to structure1; otherwise, No. If overwrite is YES or TRUE, keys in structure2 overwrite similarly named keys in structure1.

lnmnnnni:

StructAppend( structure1, structure2, overWrite)

StructClear()

Fig. 6.21 Joint application of patch-clamp and voltageclamp methods to the study of a single potassium channel present in the membrane of a spinal-cord neuron cultivated in the tissue culture. The values indicated before each curve are potential differences imposed on the membrane. The ion channel is either closed (C) or open (O). (A simplified drawing according to B. Hille)

StructClear( structure)

Certain types of sounds, such as some guitars, ambient synths, and background vocals, can be spread across the stereo spectrum, creating a stereo effect while maintaining left/right balance. Sometimes you don t want the imbalance that panning a sound to the left or right of center can create, but you want to create stereo imagery either to help separate an element from others in the mix or create a fuller sound. There are a few techniques that will either first break a mono sound apart into components or create multiple copies of the sound, each processed slightly differently. These elements are then spread across the stereo spectrum.

StructCopy()

Fig. 6.22 A function model of the sodium channel. P denotes protein, S the potential sensitive sensor and H the gate. The negative sign marks the carboxylate group where the guanidine group of tetrodotoxin can be attached. (According to B. Hille)

Returns a structure containing a copy of structure. If you set the value of a key in a nested structure within the copy, the value in the corresponding key in the original structure is changed as well.

StructCopy( structure)

StructCount()

(0.5 x 0.4 nm in size) controlling the entrance of ions with a definite radius. The rate of transport of sodium ions through the channel is considerable: when polarizing the membrane with a potential difference 4- 60 mV a current of approximately 1.5 pA flows through the channel which corresponds to 6 x 106 Na+ ions per second practically the same value as with the gramicidin A channel. The sodium channel is only selective but not specific for sodium transport. It shows approximately the same permeability to lithium ions, whereas it is roughly ten times lower than for potassium. The density of sodium channels varies among different animals, being only 30 fim~2 in the case of some marine animals and 330 jurn"2 in the squid axon, reaching 1.2 x 104 fj,m~2 in the mammalian nodes of Ranvier (see Fig. 6.17). The potassium channel mentioned above (there are many kinds) is more specific for K+ than the sodium channel for Na+ being almost impermeable to Na + .

StructCount( structure)

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