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absence of subcutaneous and visceral abdominal fat from birth; triglyceride storage is markedly increased in liver and muscle, leading to severe insulin resistance, diabetes and recurrent ketosis (Robbins et al., 1984; Joffe et al., 2001) Leptin levels are very low, and appetite and food intake correspondingly increased. A similar phenotype is seen in the transgenic fatless (A-ZIP/F-1) mouse, which lacks white adipose tissue and has greatly reduced leptin levels. Severe fatty in ltration of the liver is associated with raised FFA and triglyceride levels, and with insulin resistance, hyperinsulinaemia and diabetes (Moitra et al., 1998; Reitman et al., 2000). Surgical implantation of white adipose tissue from normal mice reverses all the metabolic derangements, suggesting that these are due to the lack of white fat (Gavrilova et al., 2000). Evidence that ectopic triglyceride deposition induces insulin resistance in the affected tissues in humans includes the nding that an increased intramyocellular triglyceride content is correlated closely with muscle insulin resistance (Figure 10.11); indeed, muscle lipid content was a better predictor of impaired insulin action than adiposity (Goodpaster et al., 1997). Intracellular triglyceride accumulation could interfere with insulin signalling by increasing DAG content and thus inhibiting PKC (Figure 10.10).

13 L Zhang and M Parashar Experiments with wide area data coupling using the Seine framework In Proceedings of the 13th IEEE International Conference on High Performance Computing (HiPC 2006), Bangalore, India, December 2006 14 T Bially A class of dimension changing mapping and its application to bandwidth compression PhD thesis, Polytechnic Institute of Brooklyn, June 1967 15 LA Drummond, J Demmel, CR Mechoso, H Robinson, K Sklower, and JA Spahr A data broker for distributed computing environments In Proceedings of the International Conference on Computational Science, 2001, pp 31 40 16 V Bhat, S Klasky, S Atchley, M Beck, D McCune, and M Parashar High performance threaded data streaming for large scale simulations In Proceedings of the 5th IEEE/ACM International Workshop on Grid Computing, Pittsburgh, PA, November 2004 17 I Manuilskiy and WW Lee Phys Plasmas 7: 1381, 2000 18 Q Lu, M.

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Don t let frame borders and colors cut up your site. Design so that frame divisions add to the look of your site, or so the page appears to be frameless. Make sure the size of each frame fits the contents nicely or scrolls elegantly to present it. If you ve got a banner that s 500 pixels wide, you ll need a frame that s 500 pixels wide to properly display it. If the frame will scroll, place it so the scrollbar doesn t break up the unified look of the site. Design your content pages with the frameset in mind, remembering that their content needs to fit inside the frames and design your frameset with your site s content in mind. The frameset you choose must be able to accommodate your content. The frameset icons you choose from the Objects palette provide excellent depictions of the frameset structures. Take a look at them in Figure 15-4 or in the Objects palette itself to help you envision your page.

Rule All Customers records must have at least one associated Orders record. All Orders records must have at least one associated OrderItems record. In Customers record, Name, Street, City, State, and Zip are required. In an Orders record, Customer, Date, and DueDate are required. In an OrderItems record, Item and Quantity are required. In an OrderItems record, Quantity must be at least 1. In an OrderItems record, Quantity must normally (99% of the time) be no greater than 100. In very rare circumstances it might be greater. Only one order can be assigned a particular DueDate. X X X X X X Database Middle Tier X X X X X X UI

Peszynska, and MF Wheeler A parallel multi-block black-oil model in multi-model implementation Reservoir Simulation Symposium, In 2001 SPE Houston, TX SPE 66359, 2001 19 L Zhang and M Parashar Enabling ef cient and exible coupling of parallel scienti c applications In Proceedings of the 20th IEEE International Parallel and Distributed Processing Symposium, Rhodes Island, Greece IEEE Computer Society Press, 2006 20 L Zhang and M Parashar Seine: a dynamic geometry-based shared space interaction framework for parallel scienti c applications Concurrency Comput Pract and Exper 18(15):1951 1973, 2006 21 Netperf benchmark http://wwwnetperforg/netperf/NetperfPagehtml 22 H Abbasi, M Wolf, K Schwan, G Eisenhauer, and A Hilton XChange: coupling parallel applications in a dynamic environment In Proceedings of the International Parallel and Distributed Processing Symposium, 2004 23 M Malawski, D Kurzyniec, and V Sunderam MOCCA towards a distributed CCA framework for metacomputing.

Phase Conjugate Laser Optics, edited by Arnaud Brignon and Jean-Pierre Huignard ISBN 0-471-43957-6 Copyright # 2004 John Wiley & Sons, Inc.

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