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Division of Health Sciences and Technology (Harvard-MIT), Massachusetts Institute of Technology, 77 Massachusetts Avenue, E19-502D, Cambridge, Massachusetts, 02139 Corresponding author: sbhatia@mitedu Background 11 Liver Disease and Cell-Based Therapies 12 Cell Sources for Liver Cell-Based Therapies 13 Approaches for the In Vitro Stabilization of Primary Hepatocytes 14 Regulation of the Hepatocyte Microenvironment Toward the Development of Engineered Liver Tissue 2 Preparation of Reagents 21 Krebs-Ringer Buffer (KRB) 22 KRB with EDTA 23 Collagenase, 0055% (w/v) 24 Coating Buffer 25 OPD Substrate Buffer 26 Complete Hepatocyte Culture Medium (CHCM) 27 Blocking Buffer 28 Washing Buffer 29 Piranha Cleaning Solution 210 Hepatocyte Culture Medium, Serum Free (HCM/SF) 211 Fibroblast Culture Medium (FCM) ..

Journal of Physical Chemistry A 1998; 102(12): 2137 4 3 2154 18 Ming, Y and Russell, LM Thermodynamic equilibrium of organic-electrolyte mixtures in aerosol particles Aiche Journal 2002; 48(6): 1331 1348 19 Topping, DO, McFiggans, GB and Coe, H A curved multi-component aerosol hygroscopicity model framework: Part 1 Inorganic compounds Atmospheric Chemistry and Physics 2005; 5: 1205 1222 20 Amundson, NR, Caboussat, A, He, JW, Martynenko, AV, Savarin, VB, Seinfeld JH and Yoo, KY A new inorganic atmospheric aerosol phase equilibrium model (UHAERO) Atmospheric Chemistry and Physics 2006; 6: 975 992 21 Topping, DO, McFiggans, GB and Coe, H A curved multi-component aerosol hygroscopicity model framework: Part 2 Including organic compounds Atmospheric Chemistry and Physics 2005; 5: 1223 1242 22 Marrero, J and Gani, R Group-contribution based estimation of pure component properties.

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When the APA was reorganized during the Second World War, the AAAP was incorporated into the APA as part of the effort to make the APA more inclusive and responsive to both scienti c and professional concerns (Capshew & Hilgard, 1992) Section D, Industrial and Business, of the AAAP became APA Division 14, Industrial and Business Psychology The new division sought to ensure that appropriate standards of training and practice were maintained and that industrial psychology remained on a solid research basis Division 14 members decided to incorporate as a separate society, the Society for Industrial and Organizational Psychology (SIOP), in 1982 This was the result, in part, of dissatisfaction with what was perceived as APA s overemphasis on practice issues at the expense of science When the APS formed in 1988, SIOP membership was opened to APS members as well as APA members.

Fluid Phase Equilibria 2001; 183: 183 208 23 Atkins, PW and DePaula J Physical Chemistry WH Freeman and Company, Oxford: 2001 24 Clegg, SL and Pitzer, KS Thermodynamics of multicomponent, miscible, ionic-solutions generalized equations for symmetrical electrolytes Journal of Physical Chemistry 1992; 96(8): 3513 3520 25 Saxena, P and Hildemann, LM Water absorption by organics: survey of laboratory evidence and evaluation of UNIFAC for estimating water activity Environmental Science & Technology 1997; 31(11): 3318 3324 26 Gmehling, J Present status of group-contribution methods for the synthesis and design of chemical processes Fluid Phase Equilibria 1998; 144(1 2): 37 47 27 Chen, CC and Mathias, PM Applied thermodynamics for process modeling Aiche Journal 2002; 48(2): 194 200..

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and support from the APA and others (Addis, 2002; APA, 1995f; Chambless & Ollendick, 2001; Crits-Christoph, D. Chambless, Frank, Brody, et al., 1995; W. Sanderson, 1994; W. Sanderson & Woody, 1995). Empirically supported treatments hinge on the notion that psychological treatment approaches should always be based on solid empirical research data and supported by professional organizations such as the APA (D. Chambless & Hollon, 1998). Empirically supported treatment approaches are manualized treatments and have been developed for a variety of clinical problems such as depression (Cornes & Frank, 1994; Hollon & Beck, 1994), anxiety (M. Newman & Borkovec, 1995), conduct disordered children (Feldman & Kazdin, 1995; Schmidt & Taylor, 2002), and pain control (R. M. Hawkins, 2001). For example, cognitive and interpersonal psychotherapy have been determined to be empirically supported treatments for both depression and bulimia while exposure and response prevention have been found to be an empirically supported treatment for obsessive-compulsive disorder (D. Chambless & Ollendick, 2001; CritsChristoph et al., 1995). While many treatment approaches are based on research support, the concept of empirically supported treatments is the most recent effort to systematize service delivery to carefully studied populations and problems (D. Chambless & Hollon, 1998; Nathan & Gorman, 2002). Controversy exists over the development of approved treatment approaches for various clinical problems (B. Cooper, 2003; Ingram, Hayes, & Scott, 2000). These issues will be further discussed in detail in 14.

Despite these changes, it is clear that SIOP is the historical successor to the AAAP (Benjamin, 1997a)..

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