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a block-oriented half-duplex protocol. It is more complex than T = 0 and ensures the reliable delivery of data blocks. 15.2.1.2 Application Layer On the application layer, requests and responses between card and card reader are exchanged in so-called application protocol data units (APDUs). Command APDUs are requests from the card reader to the card, while response APDUs contain the corresponding answers of the smart card. APDUs are de ned independently of the communication protocol (T = 0 or T = 1). Command APDUs. A command APDU speci es a request to the card. It consists of a header of xed length and an optional body of variable length. The structure of command and response APDUs is shown in gure 15.1. The CLA byte speci es the instruction class, which also de nes the requested card application (e.g., 0xA0 for GSM). The INS byte is the operation code of the instruction to execute. P1 and P2 are parameters for the operation. The body of a command APDU has a variable structure, depending on whether data bytes are sent in the command APDU, expected in the response APDU, or both. The Lc byte speci es the number of data bytes, the Le byte the number of bytes expected in the response APDU. Response APDUs. They consist of an optional body, containing the application data of the answer corresponding to the request, and a mandatory trailer, consisting of a status word that indicates the correct execution of the command or the error reason.

Again, the resulting model accuracy is displayed using the format sensitivity/speci city The following model gave the best overall performance (both sensitivity and speci city) and was selected: neural network with two hidden layers, 50,000 cycles, and a learning rate of 05 using all six descriptors as inputs The overall concordance for this model was 079 (or 79%) with a speci city of 066 (66%) and a sensitivity of 086 (86%) Once the nal model has been built, it is often a valuable exercise to look at observations that were not correctly predicted Figure 912 presents a series of box plots for observations predicted to be in the not diabetes group, but who were diabetic (false positives) The upper box plot represents the set of false positives, the lower presents all observations.

1.5 1.6 1.7 1.8 1.9

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Based on our understanding of the data, diabetes is often associated with increased levels of Plasma Glucose In these examples, the patients had a lower than expected level of Plasma Glucose Other characteristics are similar to the average for the data set This indicates that we may be missing important attributes to classify these observations correctly, such as other risk factors (eg level of physical activity, cholesterol level, etc) We can also look at examples where we predicted the patients to become diabetic when in fact they did not (false negatives) A series of box plots for the descriptor variables are presented in Figure 913 The upper box plots are the false negatives and the lower box plots are all observations These patients have characteristics, based on our understanding of the data, of individuals that would go.

Practitioners should bear the following in mind: (1) Anterior positioning appliance therapy is not intended to correct the disccondyle relationship, but to facilitate the reduction in TMD symptoms, similar to other conservative TMD treatments.20 (2) Even though a patient meets the anterior positioning appliance criteria, a stabilization appliance is generally similarly effective in reducing a patient s symptoms.3,5,6 Since the anterior positioning appliance needs to be carefully followed for complications whereas the stabilization appliance has minimal complications, it is recommended that the stabilization appliance be used rst. If the

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