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The regulation of salt and water excretion by the kidneys involves all of the endothelial and epithelial transport mechanisms we have described in previous chapters, and either directly or indirectly all of those mechanisms are subject to physiological control Although it might appear to be an overwhelming task to understand their regulation, there is indeed a logic to regulation that we can easily grasp First, net salt and water excretion is the sum of all the transport processes in the glomerulus and various nephron segments, and second, that sum maintains balance However, and here is the key point, balance is not regulated on the basis of input, using physiological water meters or salt meters directing the kidneys to excrete at rates that match input Rather, renal excretion is regulated in response to the consequences of input and loss Those consequences are manifested primarily in the cardiovascular system There are many interactions between the kidneys and the cardiovascular system in which the action of one affects the other Accordingly, we can paint a big picture of renal control in the following way Control of salt and water excretion serves to (1) maintain a body fluid volume appropriate for filling the vascular tree, (2) maintain an osmolality of that fluid appropriate for the function of cells bathed in it, and (3) allow the heart to generate the arterial pressure necessary to perfuse peripheral tissues In one way or another, all of the processes discussed in the rest of this chapter fit into this picture Regulating the amount of salt and water in the body is conceptually straightforward In regulating total body salt and water, the kidneys are actually regulating 4 quantities simultaneously: water balance, salt balance, osmolality, and blood pressure When the body takes on a load of water or salt or both, the kidneys excrete these loads to maintain balance Regulating osmolality involves a juggling act Osmolality is not a substance that has an input and output; rather, it is the ratio of substances (solute and water) Therefore, the kidneys have to independently handle water loads and salt loads, all the while keeping their ratio in the body within rather tight limits Regulating blood pressure is clearly the most complex of the various renal tasks As mentioned above, it centers on maintaining a fluid volume that appropriately fills the vascular tree, but includes other actions of the kidneys. pdf compress in c# What is the best way to Compress PDF file size - C# Corner
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