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From the Components panel, drag a push button onto the Stage below the answers Change its Label parameter in the Property inspector to Next (You could also use Submit or something similar) Change its Click Handler parameter to yourAnswer This parameter is the name of a function that you define later in the ActionScript In the Instance Name text box of the Property inspector, type Mercury or the answer to the question The instance name must match the Data parameter exactly Repeat Steps 2 through 4 for each question and set of answers (In our example, the answers remain the same throughout (all nine planets), so we didn t add keyframes on the radiobuttons layer You could do the same with a true/false quiz, where the available answers are always true and false)

28 that the time interval prior to PDE-5 inhibitor use is ve half-lives, which equals ve days for the most popular once-daily oral nitrate agents

$30 20 10 100 1,000 40% 400 2,000 2,400 30 (80) 100

$36 20 16 100 1,600 40% 640 2,000 2,640 36 (73) 100

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employee or the employer must make an election to settle the award pursuant to either (but not both) the SAR or the nonstatutory stock option The form of payment for amounts earned pursuant to an SAR may be speci ed by the award (ie, stock, cash, or a combination thereof), or the award may allow the employee or employer to elect the form of payment If the award is settled in stock, the number of shares issued to the employee is determined by dividing the amount earned by the fair market value of this stock, determined as of the exercise date The employee s right to exercise an SAR normally vests after a speci ed period (eg, 5 years) and the right to exercise expires after a speci ed period (eg, 10 years) In the case of an SAR granted in tandem with a nonstatutory award (or other alternate award), the vesting and expiration dates for both awards are usually identical (ii) Accounting by Employer for Compensation Expense An SAR is a variable award, that is, the number of shares, or the amount of cash, an individual is entitled to receive is not known at the date the award is granted The measurement date and, thus, the determination of total compensation cost associated with an SAR, occur at the exercise date Total compensation, determined at the exercise date, is equal to the number of rights multiplied by the difference between the quoted market price of the employer s capital stock at the exercise date and the value speci ed in the award (normally the quoted market price of the employer s capital stock at the grant date) For purposes of allocating compensation cost to expense of interim periods between the date of grant and the measurement date, compensation cost is estimated at the end of each interim period by multiplying the number of options expected to become exercisable times the intrinsic value of each option as of the end of the period During the service period, this estimate of compensation.

To say that sildena l has transformed the management of ED would be a substantial understatement Its mechanism of action by blocking degradation of cGMP by phosphodiesterase-5 (PDE-5) promotes blood ow into the penis and the restoration of erectile function Vardena l and tadala l have been added to this family of drugs [23,24] Because their mechanism of action is the same, there is no reason to assume there will be any signi cant differences in ED effectiveness, but their half-life may be of cardiac clinical importance Hemodynamically, PDE-5 inhibitors have mild nitrate-like actions (sildena l was originally intended to be a drug for stable angina) [25] As PDE-5 is present in smooth muscle cells throughout the vasculature and the NO/cGMP pathway is involved in the regulation of BP, PDE-5 inhibitors have a modest hypotensive action In healthy men a single dose of 100 mg sildena l transiently lowered BP by an average of 10/7 mmHg, with a return to baseline after six hours There was no effect on heart rate [25] As NO is an important neurotransmitter throughout the vasculature and is involved in the regulation of vascular smooth muscle relaxation, a synergistic and clinically important interaction with oral or sublingual nitrates can occur and a profound fall in BP can result The mechanism involves the combination of nitrates increasing cGMP formation by activating guanylate cyclase and PDE-5 inhibition decreasing cGMP breakdown by inhibiting PDE-5 The concomitant administration of PDE-5 inhibitors and nitrates is a contraindication to their use and this recommendation also extends to other NO donors, such as nicorandil Clinical guidelines regarding timing of sublingual nitrate use post PDE-5 inhibitor are 24 hours for sildena l and vardena l [3] Tadala l, with its long half-life, did not react with nitrates at 48 hours after use [26] Oral nitrates are not prognostically important drugs and they can therefore be discontinued and, if needed, alternative agents substituted [27] After oral nitrate cessation, and provided there has been no clinical deterioration, PDE-5 inhibitors can be used safely It is recommended.

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